Bioactive Small Molecules
Medchemexpress LLC NADH-IN-1 | 1432445-15-2 | MFCD07109669 | 99.4% | 382.44 g·mol⁻¹ | C19H21F3N2OS | 5 MG
NADH-IN-1 is a small-molecule research inhibitor of NADH:ubiquinone oxidoreductase (complex I) supplied for laboratory use. It is provided as a high-purity solid in multiple milligram quantities and as a 10 mM solution in DMSO. CAS: 1432445-15-2; formula: C19H21F3N2OS.
Cayman Chemical Norbixin (hydrate), Purity: ≥70%, 5 mg
A carotenoid with diverse biological activities; binds to PPARγ in a cell-free assay (Ki = 1.15 µM); attenuates hyperglycemia, hyperinsulinemia, and insulin resistance, as well as decreases serum lipid levels and cardiac levels of TBARS and GSH in a rat model of cardio-metabolic syndrome at 47.7 mg/kg; decreases serum levels of oxidized LDL and aortic protein oxidation, as well as reduces atherosclerotic area, in a rabbit model of cholesterol-induced atherosclerosis; reduces mercury-induced DNA damage in isolated rat hepatocytes and leukocytes at 0.1 and 1 mg/kg; prevents photoreceptor degeneration in an Abca4-/- Rdh8-/- mouse model of AMD
Cayman Chemical β-Elemonic Acid, Purity: ≥98%, CAS: 28282-25-9, 5 mg
A triterpene with anticancer activity; inhibits growth of NSCLC A549 cells (IC50 = 6.92 µM) in vitro; induces apoptosis and cytotoxicity in A549 cells in a dose-dependent manner; inhibits phosphorylation of p42/44, MAPK/JNK, and p38 in vitro; induces ROS production and COX-2 expression in vitro; inhibits prolyl endopeptidase (IC50 = 39.74 µM) in vitro
Cayman Chemical GW 280264X, Purity: ≥95%, CAS: 866924-39-2, 10 mg
An ADAM17/TACE and ADAM10 inhibitor (IC50s = 8 and 11.5 nM, respectively); inhibits TNF-α-induced cleavage of endomucin in HUVECs at 10 µM; inhibits PMA-induced ACE2 ectodomain shedding in HEK-ACE2 cells at 1 and 10 µM; reduces ACE2 shedding and prevents SARS-CoV-2 infection in HK-2 cell
Cayman Chemical CGS 12066B, Purity: ≥98%, CAS: 109028-10-6, 25 mg
A 5-HT1B receptor agonist (IC50 = 51 nM); selective for 5-HT1B over 5-HT1A and 5-HT2 receptors (IC50s = 876 and 6,480 nM, respectively), as well as α1-, α2-, and β-adrenergic and dopamine D1 and D2 receptors (IC50s = >6,000, >1,000, >1,000, >5,000, and >5,000 nM, respectively); inhibits forskolin-induced cAMP accumulation in opossum kidney cells from 0.001-1 µM; reduces 5-HTP accumulaiton in the the fronto-parietal cortex (ED50 = 7.92 µmol/kg) and induces dorsal raphe cell firing in rats (ED50 = 358 nmol/kg); decreases interfemale and intermale aggression in Syrian hamsters
Apexbio Technology LLC JNJ-26481585, 10mg. Cas: 875320-29-9 MFCD: MFCD17010272. Potent HDAC inhibitor
JNJ-26481585 is a novel histone deacetylase (HDAC) inhibitor that exerts a strong potency towards class I HDAC (including HDAC1, HDAC2 and HDAC3), with values of inhibition constant IC50 of 0.11, 0.33 and 4.8 nmol/L respectively. Other sizes are available. Please inqury us for quote.
Selleck Chemical LLC Trimethoprim E4837-1G
Trimethoprim (lactate) is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR) an essential enzyme responsible for the production of tetrahydrofolic acid (THF) By blocking this enzyme trimethoprim prevents the synthesis of bacterial DNA hindering bacterial survival It is a standard antibiotic for treating urinary tract infections (UTIs)
Medchemexpress LLC B7-1/CD80 Cynomolgu 50ug
CD80 is a costimulatory cytokine for cancer immunity that is activated by binding to CD28 or CTLA-4 Tumor immune evasion occurs when CD80 expression is low The increased expression of CD80 induced by TP53 stimulates anti-tumor immune responses B7-1/CD80 Protein Cynomolgus (HEK293 His) is the recombinant cynomolgus-derived B7-1/CD80 protein expressed by HEK293 with C-6 His labeled tag
Medchemexpress LLC HY-135391 1mg , Ezetimibe phenoxy glucuronide CAS:190448-57-8 Purity:>98%
HY-135391 1mg Ezetimibe phenoxy glucuronide CAS: 190448-57-8 Ezetimibe phenoxy glucuronide (Ezetimibe glucuronide) is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity. Ezetimibe is a potent cholesterol absorption inhibitor. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Raf inhibitor 1 | 1093100-40-3 | 98.0% | C26H19ClN8 | 50 MG
Raf inhibitor 1 is a potent Raf kinase inhibitor with Ki values of 1 nM, 1 nM, and 0.3 nM for B-RafWT, B-RafV600E, and C-Raf, respectively. It inhibits A375 and HCT-116 proliferation with IC50s of 0.31 and 0.72 μM. This inhibitor binds to and stabilizes B-Raf in a DFG-out, inactive conformation where the ATP pocket is partially filled by Phe595 and Gly596 from the DFG motif. It also shows low micromolar inhibition against wild type B-Raf cell lines, which may be due to off-target kinase activities or pan-Raf inhibition, including Raf dimers. This product is for research use only.
- Potent Raf kinase inhibitor
- Inhibits B-RafWT, B-RafV600E, and C-Raf
- Inhibits A375 and HCT-116 proliferation
- Binds to and stabilizes B-Raf in an inactive conformation
- Suitable for research applications
Medchemexpress LLC BRD-6929 | 849234-64-6 | MFCD16495786 | 99.5% | 351.4 g/mol | C19H17N3O2S | 25 MG
BRD-6929 is a potent, selective, brain-penetrant inhibitor of class I histone deacetylases HDAC1 and HDAC2, showing low-nanomolar inhibitory activity and high binding affinity. It is used in preclinical research, including CNS and mood-related behavioral model studies, for target validation and pharmacology characterization.
- Potent HDAC1 and HDAC2 inhibition (IC50 1 nM and 8 nM).
- High binding affinity to targets (Ki 0.2 nM and 1.5 nM).
- Brain-penetrant properties suitable for CNS research.
- Applicable to mood-related behavioral model studies and target validation.
- Supplied in small research quantities for preclinical experiments.
AdipoGen 9,10-Anthracenedipropanoic acid (100 mg)
Chemical. CAS: 71367-28-7. Formula: C20H18O4. MW: 322.36. 9,10-anthracenedipropanoic-acid (ADPA) is a fluorescent singlet oxygen acceptor. It is a ROS indicator/quenching probe and can be used for the detection of singlet oxygen (O2). ADPA can selectively react with one O2 (a typical ROS), resulting in a corresponding decrease in its absorbance. ADPA is also used as a building block for synthesis of new singlet oxygen acceptors. The sodium salt can be produced by addition of NaOH.
Medchemexpress LLC CTLA-4 Mouse HEK29 10ug
CTLA-4 Protein, Mouse (HEK293, His) is a recombinant extracellular domain of mouse CTLA-4 expressed in HEK293 cells and supplied lyophilized with a C-terminal 6xHis tag. The product covers residues A37-D161, is formulated in phosphate buffer with physiological salt, and is intended for research use only. Follow the manufacturer's reconstitution and storage recommendations for best activity retention.
- Expressed in HEK293 for mammalian post-translational modifications.
- Includes a C-terminal 6xHis tag for purification and detection.
- Covers residues A37-D161, representing the extracellular domain.
- Lyophilized formulation for improved stability and transport.
- Formulated in 20 mM PB, 150 mM NaCl, pH 7.4 for physiological compatibility.
- Recommended handling: avoid reconstituting below 100 μg/mL and aliquot for long-term storage.
- For research use only; not for diagnostic or therapeutic applications.
Medchemexpress LLC Rifamycin S | 13553-79-2 | MFCD06198807 | 98.8% | 695.8 g/mol | C37H45NO12 | 50G
Rifamycin S is a rifamycin-class antibiotic research compound that inhibits bacterial DNA-dependent RNA polymerase. It is supplied as a purified reference material for biochemical and microbiological studies, and is used in antimicrobial research, mechanism-of-action experiments, and assay development.
- High purity suitable for research experiments (98.8%).
- Acts as an RNA polymerase inhibitor for bacterial studies.
- Available in multiple pack sizes for small-scale and bulk use.
- Offered as solid and as DMSO solution options for convenience.
- Covers essential identifiers: CAS 13553-79-2, formula C37H45NO12, molecular weight 695.8 g/mol.
- Datasheet, COA, and SDS are available to support use and safety compliance.
Medchemexpress LLC N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((3-fluorophenyl)sulfinyl)-2-hydroxy-2-methylpropanamide | 1539314-06-1 | MFCD30343844 | 99.4% | 330.33 g/mol | C14H13F3N2O2S | 50 MG
GSK-2881078 is an orally active, nonsteroidal selective androgen receptor modulator (SARM) used for preclinical research into muscle wasting and cachexia. It shows tissue-selective AR activity and induces AR-mediated transcriptional activation in cellular assays (PC3(AR)2 EC50 = 3.99 nM).
- Orally active, nonsteroidal SARM suitable for in vitro and preclinical studies.
- Tissue-selective AR modulation with potent receptor activation (EC50 = 3.99 nM in PC3(AR)2 cells).
- High reported purity of 99.42% (supplier data).
- Molecular formula C14H13F3N2O2S; molecular weight 330.33 g/mol.
- Available as solid and as 10 mM solution in DMSO for convenience in assays.
- CAS number 1539314-06-1 provided for unambiguous identification.