Bioactive Small Molecules
Cayman Chemical ANTIBODY PQR530 25mg
A dual inhibitor of PI3Kα and mTOR (IC50s = 11.1 and 7.4 nM, respectively); inhibits phosphorylation of Akt and ribosomal S6 kinase in A2058 melanoma cells (IC50s = 62.2 and 61.1 nM, respectively); inhibits cell growth in a panel of 66 cancer cell lines (mean GI50 = 0.43 µM); reduces tumor growth in an OVCAR-3 mouse xenograft model at 25 mg/kg; decreases the number of seizures per week in a Tsc1GFAP conditional knockout mouse model of epilepsy
Medchemexpress LLC RDR 02308 | 4155-82-2 | C19H15N3O3 | 5 MG
RDR 02308 is a TLR4-MyD88 binding inhibitor that inhibits full-length β-lactamase, intended for research use only. In vitro studies show that RDR 02308 (0-10 μM; 1 h) inhibits LPS-mediated IL-6 production in RAW264.7 cells.
- Inhibits TLR4-MyD88 binding.
- Inhibits full-length beta-lactamase.
- Intended for research use only.
- Inhibits LPS-mediated IL-6 production in RAW264.7 cells.
- Available in solid form.
- Yellow to orange color.
- Soluble in DMSO at 100 mg/mL.
- Store powder at -20°C for up to 3 years or 4°C for up to 2 years.
- Store in solvent at -80°C for up to 6 months or -20°C for up to 1 month.
Cayman Chemical ANTIBODY INCB 3344 5mg
An antagonist of CCR2 (IC50 = 10 nM); selective for CCR2 over a panel of G protein-coupled receptors, including CCR1 and CCR5, with IC50s values >1 µM; inhibits MCP-1-induced chemotaxis of WEHI-274 cells (IC50 = 10 nM); inhibits monocyte influx in a thioglycolate-induced mouse model of peritonitis at 60 and 100 mg/kg; decreases the expression of CCR2 mRNA in the EAr and reduces EAr swelling in a mouse model of delayed-type hypersensitivity reaction at 30, 50, and 100 mg/kg twice per day; prevents increases in or reduces macrophage levels in the spinal cord at 100 mg/kg per day beginning the day of immunization or seven days following immunization, respectively, in a mouse model of EAE
Medchemexpress LLC Isobutamben | 94-14-4 | 100 MG
Isobutamben (Standard) is the analytical standard of Isobutamben (HY-B1665). It is intended for research and analytical applications and is an amino ester-type local anaesthetic agent. This compound is a reference standard supplied assay, commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Analytical standard for Isobutamben
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
- Amino ester-type local anaesthetic agent
- For research use only
Cayman Chemical ANTIBODY PD 174265 500ug
A potent, cell-permeable inhibitor of the tyrosine kinase activity of the epidermal growth factor (EGF) receptor (IC50 = 0.45 nM); effective in cells, blocking tyrosine phosphorylation induced by either EGF or heregulin (IC50s = 39 and 220 nM, respectively)
Medchemexpress LLC Dbco-peg5-dbco | 2363130-04-3 | MFCD28334545 | 98.0% | 854.99 g/mol | C50H54N4O9 | 5 MG
DBCO-PEG5-DBCO is a bifunctional polyethylene glycol (PEG) linker bearing two dibenzocyclooctyne (DBCO) groups for copper-free click conjugation to azide-functionalized molecules. Supplied as a dry reagent for research-scale bioconjugation, PROTAC assembly, and probe development, it offers defined spacer length and high purity to support reliable coupling performance.
- Enables copper-free strain-promoted azide-alkyne cycloaddition.
- Contains two DBCO reactive termini for bifunctional linking.
- PEG5 spacer reduces steric hindrance and improves solubility.
- High purity supports reproducible bioconjugation.
- Supplied in small-quantity packs for research-scale synthesis.
Cayman Chemical VTP27999trIfluoroacetAT s 5mg
A renin inhibitor (IC50 = 0.47 nM for the recombinant human enzyme); selective for renin over β-secretase, cathepsin D, and cathepsin E at 10 µM; >1,000-fold selective for renin over a panel of >250 receptors, ion channels, and enzymes; reduces mean arterial pressure in a double-transgenic rat model of angiotensin II-dependent hypertension at 10 mg/kg
Cayman Chemical NDesmethyltamoxIfenhydroch 5mg
An active metabolite of tamoxifen; inhibits PKC (IC50 = 8 µM for the rat enzyme); decreases iron (III) chloride and ascorbate-induced increases in TBARS in rat liver microsomes (IC50 = 17.5 µM); induces relaxation in isolated and washed rat aortic rings (pD2 = 9)
AdipoGen SPulegone
Chemical. CAS 3391-90-0. Formula C10H16O. MW BD9837. S-Pulegone is a monoterpene utilized as a particularly actractive chiral starting material for the synthesis of more complex natural products. This compound has also shown to have antimalarial properties.
Cayman Chemical ANTIBODY NVP-TAE226 1mg
A FAK inhibitor (IC50 = 5.5 nM) that also inhibits IGF-1R (IC50 = 0.16 µM); inhibits glioma and ovarian tumor growth in in vivo tumor models
Selleck Chemical LLC STING agonist-15mg
STING agonist-1 (G10) is a novel human-specificSTING agonist that triggersIFN regulatory factor 3 (IRF3)/ type I interferon (IFN)-associated transcription in human fibroblasts. STING agonist-1 (G10) potently reduces growth of Chikungunya virus (CHIKV) with IC90 of 8.01 ?M and blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 ?M. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC Katacalcin | 85916-47-8 | 98.3% | 2436.60 | 10 MG
Katacalcin is a potent plasma calcium-lowering peptide that belongs to the calcitonin family. It causes a rapid but short-lived drop in blood calcium and phosphate levels by promoting their incorporation into bones. It is also involved in regulating human CD14+ peripheral blood mononuclear cell (PBMC) migration.
- Potent plasma calcium-lowering peptide.
- Belongs to the calcitonin family.
- Promotes the incorporation of calcium and phosphate into bones.
- More potent inhibitor of fMLP-induced chemotaxis than calcitonin (CT) or procalcitonin (PCT) at specific concentrations.
- Deactivates CD14+ PBMC chemotaxis towards various attractants.
- Regulates human CD14+ PBMC migration via protein kinase A-dependent cAMP pathways.
- High purity of 98.29%.
Apexbio Technology LLC Phenelzine sulfate 156-51-4 100mg
Phenelzine sulfate (CAS 156-51-4) is a small-molecule inhibitor of monoamine oxidase (MAO) targeting both MAO-A and MAO-B isoforms By blocking MAO activity phenelzine sulfate limits the enzymatic degradation of monoamine neurotransmitters including norepinephrine serotonin and dopamine resulting in elevated synaptic levels This modulation of neurotransmitter availability underpins its utility in neuropharmacological research on mood regulation neurochemical signaling and mechanistic studies of neurotransmitter dynamics Phenelzine sulfate is commonly utilized to investigate the molecular and cellular effects of altered monoaminergic transmission in neuroscience and psychiatric research models
Medchemexpress LLC Nomilin | 1063-77-0 | 514.56 | 1 ML
Nomilin is a limonoid compound derived from citrus fruits, primarily functioning as an anti-obesity and anti-hyperglycemic agent.
- Derived from citrus fruits
- Acts as an anti-obesity agent
- Functions as an anti-hyperglycemic agent
- Mitigates cell death and reduces ROS production in SH-SY5Y cells
- Attenuates blood-brain barrier disruption in MCAO rats
Medchemexpress LLC STING agonist-23 | 2361570-16-1 | C33H35N13O4 | 5 MG
STING agonist-23 (CF502) is a non-nucleotide small-molecule STING agonist. It activates STING and increases the phosphorylation of STING, TBK1, and IRF3. It promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells, and shows activity against SARS-CoV series strains.
- Activates STING, increasing the phosphorylation of STING, TBK1, and IRF3.
- Elevates levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells.
- Demonstrates activity against SARS-CoV series strains.
- Induces a strong antibody immune response when combined with SARS-CoV-2 RBD-Fc protein in a mouse model (adjuvant activity).